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氟尿嘧啶植入剂在原发性肝癌治疗中的研究进展
 发布时间:2022/7/16 浏览次数:254

氟尿嘧啶植入剂在原发性肝癌治疗中的研究进展
作者:唐忠浩1  黄建钊1 2  刘延2  沈素雅1 
单位:1.贵州医科大学 贵阳 550000 2.贵州省人民医院 肝胆外科 贵阳 550000 
关键词:原发性肝癌 氟尿嘧啶植入剂 治疗效果 
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出版年,卷(期):页码:2022,14(1):14-18
摘要:
摘要:原发性肝癌是全世界最常见的肿瘤之一,在我国居常见恶性肿瘤第4位和肿瘤致 死病因第2位。肝癌术后复发率和转移率均较高,而其原因可能是术中残留的微量癌细 胞在机体处于免疫功能抑制状态下进入增殖期。氟尿嘧啶作为细胞周期特异性药物,其 在体内转化形成的活性代谢产物与胸腺嘧啶合成酶形成稳定复合物,使DNA和RNA无 法正常进行复制,是其发挥抗肿瘤作用的主要机制。氟尿嘧啶植入剂作为一种缓释剂药 物,能以高浓度形式在植入局部区域持续起到抗肿瘤作用,且全身不良反应较小,对胃 癌、结直肠癌、乳腺癌和肝癌均有一定疗效。在肝癌切除术中植入氟尿嘧啶植入剂可有 效降低术后甲胎蛋白等肿瘤指标物水平及术后复发率,提高患者术后缓解率和生存时 间,无明显并发症和不良反应。氟尿嘧啶植入剂可观的临床效果为目前肝癌的治疗带来 了新的思路,本文就氟尿嘧啶植入剂在肝癌治疗中的研究现状和进展进行综述。
Abstract: Primary liver cancer is one of the most common tumors in the world, and it is also the fourth most common malignant tumor and the second cause of tumor death in China. Both the postoperative recurrence and metastasis rates of primary liver cancer are high, the reason may be the minimal residual cancer cells after surgery, which can enter proliferation period at the moment when human body is in an immunosuppressive state. As a cell cycle-specific drug, fluorouracil can form stable complexes with thymine synthetase in body, which causes the failure of DNA and RNA’s replication. Fluorouracil implants, as a slow-release drug, play an anti-tumor role in the form of high concentrations in the implanted local areas, without the toxic side effects of systemic chemotherapy and have a certain curative effect on gastric cancer, colorectal cancer, breast cancer and liver cancer. The implantation of fluorouracil implants in liver cancer resection can effectively reduce the level of tumor indicators such as postoperative alpha fetoprotein, and can also reduce the recurrence rate after surgery, increasing the postoperative remission rate and survival time, and have no obvious complications and adverse reactions. The considerable clinical effect of fluorouracil implants has brought new ideas to the treatment of liver cancer. The research progress on fluorouracil implants in the treatment of primary liver cancer were reviewed in this paper.
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